Hippo Yap. The hippo yap pathway also. Although hippo yap signaling activity is highly contextual measuring yap phosphorylation states governing nuclear versus cytoplasmic localization can be used as a proxy for pathway activity figure 3a zhao et al 2007.
Mechanical cues generated by blood flow can either activate or inhibit yap. The hippo yap pathway also. Unlike other conventional signaling pathways hippo yap signaling is impacted and activated by architectural and mechanical cues and actin cytoskeleton is an important mediator of hippo yap.
Dysregulation is implicated in the development of multiple cancers.
Indeed the localization and. Unphosphorylated yap is active and accumulates in the nucleus while yap s127 phosphorylation converts yap to an inactive. We found that knockout ko of mst1 and mst2 two key components of the hippo signaling in mouse embryonic stem cells escs resulted in a disruption of differentiation into mesendoderm lineage. The hippo yap pathway has been well documented in organ size control tissue homeostasis and cancer.